Five years experience of photodynamic therapy with new chlorin photosensitizer

Valery A. Privalov; Alexander V. Lappa; Elena V. Kochneva

doi:10.1117/12.633098

26 August 2005 Five years experience of photodynamic therapy with new chlorin photosensitizer

Valery A. Privalov, Alexander V. Lappa, Elena V. Kochneva

Proceedings Volume 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II; 586310 (2005) https://doi.org/10.1117/12.633098
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Clinical results of photodynamic therapy (PDT) with a novel natural second generation chlorin-type photosensitizer "Radachlorin", mainly consisting of sodium chlorine e6, are presented. This sensitizer possesses a number of advantages over sensitizers of hematoporphyrin and phthalocyanine types. In particular, Radachlorin is excreted from organism much faster (in 1-2 days), as a result the problem of patient light hypersensitivity for a few months is non-actual for Radachlorin. As light source there was used a 662 nm diode laser specially designed for PDT with Radachlorin. The 5 year clinical results of PDT application to 89 patients with different malignant tumors are summarized and analysed. It is shown in particular that PDT with Radachlorin is a radical high efficient method for treatment of basal cell carcinoma of skin. At intravenous introduction in drug dose 0.5 mg/kg with light fluence 300-350 J/cm2 or in dose 1 mg/kg with fluence 200-250 J/cm2 the method gives full recovery in almost 100% cases with excellent cosmetic effect. The method was successfully combined with surgical operations, laser ablations, radio- and chemotherapy. Preoperative and intraoperative PDT favors improvement of results in complex treatment of malignant tumors. The method has a potential as palliative measure; in a number of incurable cases it allowed us to achieve recanalization of obturated hollow organs, eliminate the inflammatory complications, and as a result to improve life quality.

Citation Download Citation

Valery A. Privalov, Alexander V. Lappa, and Elena V. Kochneva "Five years experience of photodynamic therapy with new chlorin photosensitizer", Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 586310 (26 August 2005); https://doi.org/10.1117/12.633098

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