26 August 2005 Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement
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We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1x10-4 RIU per degree phase change.
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H. P. Ho, H. P. Ho, K. S. Chan, K. S. Chan, C. L. Wong, C. L. Wong, K. F. Lei, K. F. Lei, W. J. Li, W. J. Li, W. C. Law, W. C. Law, S. Y. Wu, S. Y. Wu, S. K. Kong, S. K. Kong, C. Lin, C. Lin, } "Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement", Proc. SPIE 5927, Plasmonics: Metallic Nanostructures and Their Optical Properties III, 59270E (26 August 2005); doi: 10.1117/12.619180; https://doi.org/10.1117/12.619180

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