Nanomaterials have gained considerable importance in various fields such as chemistry, physics, materials science, biology, and bio-engineering due to the great demand in designing nanomaterial with controlled size, shape and physico-chemical properties. The conventional methods for the preparing metal chalcogenide suffer from several limitations, such as high processing temperature, relatively high cost, non-stoichiometric compositions and poor crystallinity. Metal chalcogenide particles with fine size and spherical morphology and non-aggregation have important applications for the on going technological advancement. It is important to develop a process that can produce particles having controlled characteristics such as morphology, composition and size. In recent years, sonochemistry offers an advantageous alternate in design of nanomaterial with desired properties. This review is mainly focused on the preparation of nanosized metal chalcognide using sonochemistry and their practical applications.