18 August 2005 The use of surface enhanced absorption, scattering and catalytic properties of gold nanoparticles in some bio- and biomedical applications
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Abstract
Gold nanoparticles with unique optical properties offer useful applications in biotechnology. In this article two applications that we have developed are summarized, in one they are used in cancer cell diagnostics and in the other they are found to have catalytic property for the NADH oxidation reaction which is important in ATP formations. By conjugation with anti-EGFR antibodies which specifically target EGFR that are usually overexpressed on most cancer cells, gold nanoparticles are used as a molecular contrast agent for cancer cell diagnostics using their both strong surface plasmon absorption and efficient Mie scattering properties. Au nanoparticles are also good catalysts for many reactions due to their high surface to volume ratio. Au nanoparticles are found to be the catalyst for the NADH oxidation reaction. This was studied by monitoring the effect of the nanoparticles on NADH fluorescence intensity and lifetime as well as the change of the surface plasmon absorption band during the reaction.
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Xiaohua Huang, Xiaohua Huang, Ivan H El-Sayed, Ivan H El-Sayed, Mostafa A. El-Sayed, Mostafa A. El-Sayed, } "The use of surface enhanced absorption, scattering and catalytic properties of gold nanoparticles in some bio- and biomedical applications", Proc. SPIE 5929, Physical Chemistry of Interfaces and Nanomaterials IV, 59290I (18 August 2005); doi: 10.1117/12.625431; https://doi.org/10.1117/12.625431
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