Applications of dynamic light scattering, fluorescence microscopy and fluorescence spectroscopy in DB-67 liposomal formulation studies

Stefan Kruszewski; Blanka Ziomkowska; Michał Cyrankiewicz; Lori Latus; David Bom

doi:10.1117/12.639044

6 December 2006 Applications of dynamic light scattering, fluorescence microscopy and fluorescence spectroscopy in DB-67 liposomal formulation studies

Stefan Kruszewski, Blanka Ziomkowska, Michał Cyrankiewicz, Lori Latus, David Bom

Author Affiliations +

Proceedings Volume 5945, 14th Slovak-Czech-Polish Optical Conference on Wave and Quantum Aspects of Contemporary Optics; 59451M (2006) https://doi.org/10.1117/12.639044
Event: 14th Slovak-Czech-Polish Optical Conference on Wave and Quantum Aspects of Contemporary Optics, 2005, Nitra, Slovakia

Abstract

Campthothecin (CPT) and its analogues as prominent anticancer agents are currently the subject of the intensive studies. One of the most promising camptothecin analogues is 7-tert-butyldimethylsil- 1 0-hydroxycampthothecin called DB-67. It is characterized by high affinity to SUV (small unilamellar lipids vesicles) and relatively high stability in human blood. The studies of liposomal formulation as a delivery systems for DB-67 are the subject of this paper. The methods of dynamic light scattering (DLS), fluorescence microscopy (FM) and fluorescence spectroscopy (FS) are used to determine the physical properties of DB-67 liposomal formulation.

Citation Download Citation

Stefan Kruszewski, Blanka Ziomkowska, Michał Cyrankiewicz, Lori Latus, and David Bom "Applications of dynamic light scattering, fluorescence microscopy and fluorescence spectroscopy in DB-67 liposomal formulation studies", Proc. SPIE 5945, 14th Slovak-Czech-Polish Optical Conference on Wave and Quantum Aspects of Contemporary Optics, 59451M (6 December 2006); https://doi.org/10.1117/12.639044

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