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29 September 2005 Trends in biothermophotonics and bioacoustophotonics of tissues
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Abstract
Recent trends in bioacoustophotonics and biothermophotonics of tissues are presented. The presentation is centered on the development of well-known frequency-domain photothermal and photoacoustic techniques to address issues associated with diffuse photon density waves during optical excitation of turbid media, both in hard tissues (teeth) and soft tissues. These methods have concrete advantages over the conventional pulsed-laser counterparts. In Part I we present biothermophotonic principles and applications to the detection of the carious state in human teeth as embodied by laser photothermal radiometry supported by modulated luminescence. The emphasis is on the abilities of these techniques to approach important problems such as the diagnosis of occlusal pits and fissures and interproximal lesions between teeth which normally go undetected by x-ray radiographs. In Part II we present theoretical and experimental results in frequency-domain bioacoustophotonics of turbid media, such as soft tissues, and we describe the development of sensitive sub-surface imaging methodologies which hold the promise for sensitive diagnostics of cancerous lesions in e.g. a human breast. Results using tissue phantoms and ex-vivo specimens are discussed and the current level of subsurface lesion sensitivity compared to state-of-the-art pulsed photoacoustic techniques is examined. In summary, advances in coupled frequency-domain diffuse-photon-density-wave and thermal or thermoelastic responses of turbid media constitute new trends in bioacoustophotonics and biothermophotonics promising for their signal quality and high dynamic range.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
A. Mandelis, R. J. Jeon, S. Telenkov, Y. Fan, and A. Matvienko "Trends in biothermophotonics and bioacoustophotonics of tissues", Proc. SPIE 5953, Acousto-optics and Photoacoustics, 595301 (29 September 2005); https://doi.org/10.1117/12.621769
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