11 September 2006 The relativity between cytokines and psoriasis and the influence on its variation induced by ILLLI
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Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 59671G (2006) https://doi.org/10.1117/12.639323
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China
Abstract
Objective: To explore the relativity between cytokines such as IL-8, TNF-α, VEGF and psoriasis and the influence on its variation by ILLLI. Methods: 47 patients with psoriasis were divided into 5 groups, treated with ILLLI (1h per day, a course of treatment is 10 days), observed the variation of IL-8, TNF-α and VEGF in peripheral blood of patients with psoriasis between pre and post treatment and compared with the control. Results: 1. In each case of psoriasis, the concentration of IL-8 in blood was significantly higher than that of control group. After treatment, the concentrations of A group, B group and C group were decreased significantly, which were close to the control. The related statistical analysis showed significant difference. Among them, A group decreased most significantly; Although there is no significant difference in concentration of IL-8 of D group and E group between pre and post treatment, the trend of them became to keep decreasing. In each case of psoriasis, the concentration of TNF-α in blood was much lower than that of control group. The concentration of TNF-α in A, C, D group increased significantly as compared with pre-irradiation except that in E group. In cases, the concentrations of VEGF in blood were much higher than that of control group. In each group, there was no difference in VEGF concentration between pre and post irradiation. Conclusions: The decrease of IL-8 induced by ILLLI might be related with its immunosuppressive function. It suppressed the activity of CD4+T cell which could secrete a great deal of IL-8 and play an important role to the tache of psoriasis onset. So in the psoriasis patients who were treated with ILLLI, the production of TNF-α could be suppressed. In patients, the increasing of VEGF might be related with the increasing of IL-8. There was no difference of it between pre and post ILLLI treatment might because VEGF was not the action target of ILLLI.
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Jing Zhu, Jing Zhu, Fan Nie, Fan Nie, Xiawen Yuan, Xiawen Yuan, Meijue Zhang, Meijue Zhang, } "The relativity between cytokines and psoriasis and the influence on its variation induced by ILLLI", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59671G (11 September 2006); doi: 10.1117/12.639323; https://doi.org/10.1117/12.639323
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