25 October 2005 Photo diagnosis of early pre cancer (LSIL) in genital tissue
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Abstract
Permanent infections recognized as oncogenic factor. STD is common concomitant diseases in early precancerous genital tract lesions. Simple optical detection of early regressive pre cancer in cervix is the aim of this study. Hereditary immunosupression most likely is risk factor for cervical cancer development. Light induced fluorescence point monitoring fitted to live cervical tissue diagnostics in 42 patients. Human papilloma virus DNR in cervix tested by means of Hybrid Capture II method. Ultraviolet (337 nm) laser excited fluorescence spectra in the live cervical tissue analyzed by Principal Component (PrC) regression method and spectra decomposition method. PCr method best discriminated pathology group "CIN I and inflammation"(AUC=75%) related to fluorescence emission in short wave region. Spectra decomposition method suggested a few possible fluorophores in a long wave region. Ultraviolet (398 nm) light excitation of live cervix proved sharp selective spectra intensity enhancement in region above 600nm for High-grade cervical lesion. Conclusion: PC analysis of UV (337 nm) light excitation fluorescence spectra gives opportunity to obtain local immunity and Low-grade cervical lesion related information. Addition of shorter and longer wavelengths is promising for multi wave LIF point monitoring method progress in cervical pre-cancer diagnostics and utility for cancer prevention especially in developing countries.
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A. Vaitkuviene, A. Vaitkuviene, S. Andersen-Engels, S. Andersen-Engels, E. Auksorius, E. Auksorius, N. Bendsoe, N. Bendsoe, V. Gavriushin, V. Gavriushin, U. Gustafsson, U. Gustafsson, J. Oyama, J. Oyama, S. Palsson, S. Palsson, M. Soto Thompson, M. Soto Thompson, U. Stenram, U. Stenram, K. Svanberg, K. Svanberg, V. Viliunas, V. Viliunas, M. J. De Weert, M. J. De Weert, } "Photo diagnosis of early pre cancer (LSIL) in genital tissue", Proc. SPIE 5968, Laser Florence 2004: A Window on the Laser Medicine World, 596802 (25 October 2005); doi: 10.1117/12.659976; https://doi.org/10.1117/12.659976
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