25 October 2005 Interaction of Er:YAG laser radiation with ureter tissue
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The aim of the work was to investigate the possibility of the ureter wall perforation by Er:YAG laser radiation and to explore the basic interaction characteristics for ureter surface and its deep structures. For these experiments Er:YAG laser system (wavelength 2.94 μm) working in free-running and Q-switched regime was utilized. Laser radiation was delivered to the investigated tissue by a special waveguide system. The basic part was a cyclic olefin polymer-coated silver hollow glass waveguide (inner/outer diameter 700/850 μm or 320/450 μm). Sealed cap of the waveguide was used for contact treatment. Maximum interaction pulse energy and length for free-running Er:YAG I laser with the 700μm waveguide were 100mJ and 200μs, respectively (corresponding intensity was 130 kW/cm2). Similarly the maximum interaction pulse energy and length for free-running Er:YAG II laser with the 320 μm waveguide were 80 mJ and 200 μs , respectively (corresponding intensity was 500 kW/cm2). Maximum interaction pulse energy and length in Q-switched regime were 17 mJ and 70 ns, respectively (corresponding intensity 63 MW/cm2). The number of pulses needed to perforate the ureter wall tissue (thickness ~1 mm) for using long 200 μs Er:YAG pulses (thermal ablation) and short 70 ns Er:YAG pulses (photoablation) was found. From the histological evaluation it follows that the application of Q-switched Er:YAG laser radiation on ureteral tissue resulted in minimum adjacent tissue alteration (up to 50μm from the surface) without any influence on the deeper layers.
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Helena Jelínkova, Petr Koranda, Michal Němec, Jan Šulc, Oto Köhler, Pavel Drlík, Mitsunobu Miyagi, Yi-Wei Shi, Yuji Matsuura, "Interaction of Er:YAG laser radiation with ureter tissue", Proc. SPIE 5968, Laser Florence 2004: A Window on the Laser Medicine World, 59680A (25 October 2005); doi: 10.1117/12.660045; https://doi.org/10.1117/12.660045


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