13 October 2005 Photoluminescence-based detection of human chronic total occlusion in peripheral vessels
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The work is devoted to photoluminescent investigation of arterial walls in order to create a new navigation method for minimally invasive treatment of cardiovascular decease in the presence of chronic total occlusions. The method uses the distinct photoluminescent properties of arterial wall and chronic total occlusion plaque to alert the interventionalist when a fiber-optic equipped catheter is in contact with the vessel wall. We conducted a study to compare the photoluminescence properties of healthy and stenosed vessel walls, and a typical chronic total occlusion plaque in the spectral range 300-700 nm. All samples were obtained from human tibial arteries. These groups of arterial samples showed easily differentiable luminescence amplitude and spectral characteristics. The photoluminescent properties of intact and intentionally damaged vessel walls were also investigated to permit detection of artery perforation that could take place during the revascularization. Using optical excitation of different wavelength gives additional opportunities of detecting arterial plaques requiring laser treatment. The results presented are complemented with micro-computed tomography images and histology of the segments analyzed.
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Ludmila Bakueva, Lukasz Brzozowski, Brian Courtney, Nikita Reznik, Stephen E. Fremes, J. A. Rowlands, "Photoluminescence-based detection of human chronic total occlusion in peripheral vessels", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 596918 (13 October 2005); doi: 10.1117/12.628153; https://doi.org/10.1117/12.628153

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