13 October 2005 Near-infrared hyperspectral imaging: the road traveled to a clinical burn application
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The process of taking a concept to a clinical device begins with the idea for a technological solution to an unmet clinical challenge. Burns are one of the most destructive insults to the skin causing damage, scarring, and in some cases death. The approach most commonly used to evaluate burns is based on the appearance of the wound. This technique is somewhat subjective and unreliable, relying on clinical experience to assess the burn. Instrument based diagnostic techniques as an adjunct to current practices has the potential to enhance the quality and timeliness of decisions concerning wound assessment and treatment. Near Infrared Spectroscopy is a promising technique that can track changes within the tissue, and can therefore provide insight as to how deep the burn actually penetrates before visual signs become apparent. Preliminary bench and animal studies were used to prove the concept of a near infrared based method of burn assessment. This study demonstrated the ability of near infrared imaging to detect and monitor the hemodynamics of burn injuries in the early post-burn period. Based on this study, a pre-prototype near infrared spectroscopic system was built with the goal of developing a reliable yet simple system that could be used in a clinical setting. A pilot clinical study was designed and implemented at the Ross Tilley Burn Center (Toronto, Canada) in order to assess the feasibility of our strategy in the clinical realm. The goal of this preliminary clinical study was to determine if the pre-prototype could be integrated into the strict regiment of an active burn centre. Both the instrument performance in a clinical setting and the injury assessment based on the analysis of near infrared reflectance measurements were a success.
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Michelle Levasseur, Michelle Levasseur, Lorenzo Leonardi, Lorenzo Leonardi, Jeri Payette, Jeri Payette, Elicia Kohlenberg, Elicia Kohlenberg, Michael Sowa, Michael Sowa, Joel S. Fish, Joel S. Fish, Karen Cross, Karen Cross, Manuel Gomez, Manuel Gomez, } "Near-infrared hyperspectral imaging: the road traveled to a clinical burn application", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 59691O (13 October 2005); doi: 10.1117/12.628233; https://doi.org/10.1117/12.628233

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