13 October 2005 Imaging tissue microstructure and microvasculature with Doppler optical coherence tomography: 3-dimensional flow phantom study
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Abstract
Time domain Doppler optical coherence tomography (DOCT) is a promising non-invasive imaging system with high spatial (~20μm) and velocity resolution (~20μm/s) that can image microvascular blood flow. It is important to understand and account for the complicated 3D nature of small blood vessels. To address this problem, two realistic flow phantoms were designed with known geometries -- an occluded flow path to model vessel narrowing, and a Y-bifurcation to simulate vessel branching. The current DOCT system produces 2D images, which when stacked sequentially can yield 3D images of microstructure and perfusion-level blood flow. 3D reconstructions allow the investigation of internal flow profiles, including an abrupt stenosis in the occluded phantom. This research will help guide our image interpretation of in-vivo DOCT studies, including treatment response monitoring in animal tumours and endoscopic assessment of the human GI tract.
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Beau A. Standish, Daina Burnes, Stephanie Chiu, Nigel R Munce, Linda Mao, Victor X. D. Yang, I. Alex Vitkin, "Imaging tissue microstructure and microvasculature with Doppler optical coherence tomography: 3-dimensional flow phantom study", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 59691R (13 October 2005); doi: 10.1117/12.628581; https://doi.org/10.1117/12.628581
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