Photodynamic Therapy (PDT) and fluorescent diagnostics (FD) using Photosense was provided in 50 patients with head and neck cancer T1-3 stage, in 89 patients with skin cancer, using Radaclorine (RC) in 42 patients with T1-4 stage basal cell carcinoma (BCC),in 6 patients with oral cancer. Detection of borders of tumor, intensity of accumulation of photosensitizers in tumor, normal tissues were done by Spectral-fluorescent Complex. We've got fluorescence of a11 tumors and additional fluorescence zones were found with cytological verification. We used semiconductive lasers: Milon - λ = 660+2nm, light dose 200 - 300 J/cm2 and Biospec (λ=672+2nm), multiple laser surface and interstitial irradiation with total light dose till 400-600 J/cm2. After PDT with PS in head and neck cancer we've had complete response (CR) in 66.0% and partial response (PR) in 30.0%, with RC CR in BCC T1-2NOMO - 92.9%, in recurrencies CR - 60,6%, PR - 39,4%. The efficacy of PDT with PS was higher (CR - 86.7%, PR - 13,3%) and the recurrence rate in 6 months lower. Our experience show pronounced efficacy of PDT for head and neck tumors of different localization and histology, FD is providing diagnostically significant information, demonstrated high sensitivity and specificity.