The synergistic use of multi-temporal and multi-spectral remote sensing data offers the possibility of monitoring of environment quality in the vicinity of nuclear power plants (NPP). Advanced digital processing techniques applied to several LANDSAT, MODIS and ASTER data are used to assess the extent and magnitude of radiation and non-radiation effects on the water, near field soil, vegetation and air for NPP Cernavoda , Romania . Cernavoda Unit 1 power plant, using CANDU technology, having 706.5 MW power, is successfully in operation since 1996. Cernavoda Unit 2 which is currently under construction will be operational in 2007. Thermal discharge from nuclear reactor cooling is dissipated as waste heat in Danube-Black -Sea Canal and Danube river. Water temperature distributions captured in thermal IR imagery are correlated with meteorological parameters. Additional information regarding flooding events and earthquake risks is considered . During the winter, the thermal plume is localized to an area within a few km of the power plant, and the temperature difference between the plume and non-plume areas is about 1.5 oC. During the summer and fall, there is a larger thermal plume extending 5-6 km far along Danube Black Sea Canal, and the temperature change is about 1.0 oC. Variation of surface water temperature in the thermal plume is analyzed. The strong seasonal difference in the thermal plume is related to vertical mixing of the water column in winter and to stratification in summer. Hydrodynamic simulation leads to better understanding of the mechanisms by which waste heat from NPP Cernavoda is dissipated in the environment.