8 November 2005 Structurally integrated organic light-emitting device (OLED)-based sensors for industrial and environmental security: sensors for hydrazine and anthrax
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Abstract
The application of the new compact platform of structurally integrated, photoluminescent (bio)chemical sensors, where the photoluminescence (PL) excitation source is an OLED, to the detection of hydrazine and anthrax, is described. The hydrazine sensor is based on the reaction between nonluminescent anthracene-2,3-dicarboxaldehyde and hydrazine or hydrazine sulfate, which generates a luminescent product. The anthrax sensor is based on a Foerster resonance energy transfer (FRET) assay, where the anthrax-secreted lethal factor enzyme cleaves certain labeled peptides at a specific site. The cleaving separates the FRET donor-acceptor pair, resulting in an increase in the PL of the donor, which was previously absorbed by the acceptor.
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Zhaoqun Zhou, Ruth Shinar, Bhaskar Choudhury, Louisa B. Tabatabai, Chuxiong Liao, Joseph Shinar, "Structurally integrated organic light-emitting device (OLED)-based sensors for industrial and environmental security: sensors for hydrazine and anthrax", Proc. SPIE 5994, Chemical and Biological Sensors for Industrial and Environmental Security, 59940E (8 November 2005); doi: 10.1117/12.631426; https://doi.org/10.1117/12.631426
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