Detection of cephradine through the electrochemical study of the degradation product of cephradine

Qingfeng Jiang; Yibin Ying; Jianping Wang; Zunzhong Ye; Yanbin Li

doi:10.1117/12.630648

9 November 2005 Detection of cephradine through the electrochemical study of the degradation product of cephradine

Qingfeng Jiang, Yibin Ying, Jianping Wang, Zunzhong Ye, Yanbin Li

Proceedings Volume 5994, Chemical and Biological Sensors for Industrial and Environmental Security; 59940V (2005) https://doi.org/10.1117/12.630648
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

The degradation product of cephradine(CEP), a broad spectrum antibiotic, with NaOH was studied in solution by Cyclic Voltammetry and Differential Pulse Voltammetry at a three electrode system (Gold working electrode, Hg/HgCl reference electrode and Platinum counter electrode). Our experiment was based on that the R-SH in degradation product could cause a deoxidization peak at gold working electrode. The response was optimized with respect to accumulation time, ionic strength, drug concentration, reproducibility and other variables. We found that the degradation product of CEP in Na₂HPO₄-NaH₂PO₄ buffer could cause a sensitive deoxidization peak at -0.68V. A linear dependence of peak currents on the concentration was observed in the range of 10^-7 - 10^-6 mol/L, with a detection limit of 0.5*10^-7mol/L. This method can achieve satisfactory results in the application of detecting human-made CEP.

Citation Download Citation

Qingfeng Jiang, Yibin Ying, Jianping Wang, Zunzhong Ye, and Yanbin Li "Detection of cephradine through the electrochemical study of the degradation product of cephradine", Proc. SPIE 5994, Chemical and Biological Sensors for Industrial and Environmental Security, 59940V (9 November 2005); https://doi.org/10.1117/12.630648

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