Many applications of fiber Bragg grating (FBG) sensors take advantage of the serial multiplexibility of these sensing devices, but the measurement application is typically restricted to a single measurand (e.g. strain). This paper discusses the use of FBG-based sensors employed as multi-parameter sensing elements where a single instrumentation system can be utilized to provide measurements of strain, temperature, pressure, acceleration, etc. FBG-based strain, temperature, and acceleration sensors are serially multiplexed to monitor a lathe cutting process. Issues regarding serial multiplexing, wavelength spacing, and sensor transducer design are discussed along with experimental examples of various sensor transducers. An experimental case of serially multiplexed acceleration, strain, and temperature sensors is shown to demonstrate the multi-parameter sensing capability of FBG sensors.