11 November 2005 Scanning laser ophthalmoscope design with adaptive optics
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Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 60070I (2005) https://doi.org/10.1117/12.630975
Event: Optics East 2005, 2005, Boston, MA, United States
Abstract
A design for a high-resolution scanning instrument is presented for in vivo imaging of the human eye at the cellular scale. This system combines adaptive optics technology with a scanning laser ophthalmoscope (SLO) to image structures with high lateral (~2 μm) resolution. In this system, the ocular wavefront aberrations that reduce the resolution of conventional SLOs are detected by a Hartmann-Shack wavefront sensor, and compensated with two deformable mirrors in a closed-loop for dynamic correction and feedback control. A laser beam is scanned across the retina and the reflected light is captured by a photodiode, yielding a two-dimensional image of the retina at any depth. The quantity of back-scattered light from the retina is small (0.001% of reflection) and requires the elimination of all parasite reflections. As an in vivo measurement, faint cellular reflections must be detected with a low-energy source, a supraluminescent laser diode, and with brief exposures to avoid artifacts from eye movements. The current design attempts to optimize trade-offs between improved wavefront measurement and compensation of the optical aberrations by fractioning the light coming to the wavefront sensor, better sensitivity by increasing the input light energy or the exposure time and the response speed of the system. This instrument design is expected to provide sufficient resolution for visualizing photoreceptors and ganglion cells, and therefore, may be useful in diagnosing and monitoring the progression of retinal pathologies such as glaucoma or aged-related macular degeneration.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sophie P. Laut, Sophie P. Laut, Steven M. Jones, Steven M. Jones, Scot S. Olivier, Scot S. Olivier, John S. Werner, John S. Werner, } "Scanning laser ophthalmoscope design with adaptive optics", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070I (11 November 2005); doi: 10.1117/12.630975; https://doi.org/10.1117/12.630975
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