17 November 2005 Chip-scale fluorescence sensors
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Proceedings Volume 6008, Nanosensing: Materials and Devices II; 60080R (2005) https://doi.org/10.1117/12.632493
Event: Optics East 2005, 2005, Boston, MA, United States
Abstract
We demonstrate an integrated fluorescence sensor chip consisting of an InGaN-GaN light emitting diode for fluorescence excitation, a bonded silicon junction photodiode for fluorescence detection, and a thin film filter for pump rejection and fluorescence selectivity. Evanescent field excitation at the LED surface is used to lessen the background due to stray pump light. The device is robust, and amenable to wafer-scale fabrication. Initial results with CdSe/ZnS quantum dot fluorophores yield a surface-bound sensitivity of 10 femtomoles, from which we predict a bulk fluid sensitivity of ~ 10 nanomolar for typical antibody-antigen assays.
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Daniel A. Cohen, Daniel A. Cohen, Hisashi Masui, Hisashi Masui, Mathew Schmidt, Mathew Schmidt, Brendan Moran, Brendan Moran, Steven P. Denbaars, Steven P. Denbaars, } "Chip-scale fluorescence sensors", Proc. SPIE 6008, Nanosensing: Materials and Devices II, 60080R (17 November 2005); doi: 10.1117/12.632493; https://doi.org/10.1117/12.632493
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