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17 November 2005 Modeling and experimental observations of gold nanoshell reflectance
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Current optical technologies utilize changes in optical properties of tissue to distinguish diseased from normal tissue. This poses an important challenge to enhance this subtle intrinsic contrast with the use of novel nanoparticle based contrast agents. Gold nanoshells are a novel type of spherical concentric nanoparticle that possesses high optical efficiencies well into the near infrared. Gold nanoshells are typically made of a dielectric silica core and a thin metallic gold outer layer and a wide range of sizes are easily fabricated using current chemistries. Gold nanoshells can scatter and/or absorb light with optical cross-sections often several times larger than the geometric cross-section. To elucidate the effectiveness of gold nanoshells as a contrast agent for reflectance, it is important to understand how different optical properties of nanoshells affect reflectance, and ultimately provide insight into how reflectance is affected by gold nanoshells embedded in biological tissue. A fiber-probe based spectrometer was used to measure diffuse reflectance of gold nanoshells suspensions from 500nm to 900nm. We further characterize diffuse reflectance of gold nanoshell suspensions using Monte Carlo based computational tools. Our results show that gold nanoshells are capable of producing large changes in diffuse reflectance, and computer modeling results agreed well with the experimental observations. From the study, we also show that it may be feasible to use Monte Carlo based modeling to simulate biological medium embedded with gold nanoshells.
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Alex W. H. Lin, Nastassja A. Lewinski, Andrey A. Rakalin, Min-Ho Lee, Naomi J. Halas, and Rebekah A. Drezek "Modeling and experimental observations of gold nanoshell reflectance", Proc. SPIE 6010, Infrared to Terahertz Technologies for Health and the Environment, 60100L (17 November 2005);

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