19 January 2006 Development of wearable medical device for Bio-MEMS
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Biomedical Micro Electro Mechanical Systems (Bio-MEMS) have been applied to the development of a variety of health care related products including health Monitoring Systems (HMS) and Drug Delivery Systems (DDS). We focus on research to develop the new type compact medical device used for blood sugar control. The new type compact medical device comprises (1) a micropump system to extract blood using a pressure change occurred by electrolysis, (2) a platinum (Pt) electrode as a blood sugar sensor immobilized Glucose Oxidase (GOx) and attached to the gate electrode of Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) to detect the amount of glucose in extracted blood, and (3) a micropump system to inject insulin using a pressure change occurred by electrolysis. The device can extract blood in a few microliter through a painless microneedle with the micropump, which used the pressure change occurred by electrolysis. The liquid extraction ability of the micropump system through a microneedle, which is 3.8 mm in length and 100 μm in internal diameter, was measured. The wearable medical device with using the micropump controlled by electrolysis could extract human blood at the speed of 0.15 μl/sec. If the wearable medical device extracts human blood for 6 seconds, it is enough human blood volume to measure a glucose level, compared to the amount of commercial based glucose level monitor. The compact medical device with the air bubble that occurred by electrolysis could inject insulin at the speed of 6.15μl/sec.
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Naoyuki Nakanishi, Naoyuki Nakanishi, Hidetake Yamamoto, Hidetake Yamamoto, Kazuyoshi Tsuchiya, Kazuyoshi Tsuchiya, Yasutomo Uetsuji, Yasutomo Uetsuji, Eiji Nakamachi, Eiji Nakamachi, } "Development of wearable medical device for Bio-MEMS", Proc. SPIE 6036, BioMEMS and Nanotechnology II, 60360P (19 January 2006); doi: 10.1117/12.638162; https://doi.org/10.1117/12.638162


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