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19 January 2006 Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties: application of magnetic/luminescent particles in immunoassays
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Abstract
Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium-doped gadolinium oxide (Eu:Gd2O3). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd2O3 host; a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.
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D. Dosev, M. Nichkova, R. K. Dumas, Kai Liu, and I. M. Kennedy "Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties: application of magnetic/luminescent particles in immunoassays", Proc. SPIE 6036, BioMEMS and Nanotechnology II, 60360T (19 January 2006); https://doi.org/10.1117/12.638599
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