27 October 2006 Mathematical modeling of dynamic laser coagulation during laser-induced interstitial thermotherapy
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Proceedings Volume 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine; 604709 (2006) https://doi.org/10.1117/12.709824
Event: Fourth International Conference on Photonics and Imaging in Biology and Medicine, 2005, Tianjin, China
Abstract
To describe the complex nonlinear process of laser tissue interactions during laser-induced interstitial thermotherapy (LITT), a two-dimensional mathematical model considering the dynamic changes in the physical tissue properties was developed. A modified Monte Carlo method was developed to simulate photon transport in tissue with a non-uniform optical property field, the finite volume method was used to numerically solve the Pennes bioheat equation to calculate the temperature distribution and the Arrhenius equation was used to predict the thennal damage extent. A temperature control heating method was also incorporated into present model to simulate the LITT clinical treatment to increase thermal damage volume and avoid evaporation and carbonization. The numerical results showed that the dynamic changes in the optical properties, the thermal properties and the blood perfusion rate significanfly affected the damage volume accumulation in tissue and should be included in munerical simulations of the LITT treatment.
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S. C. Jiang, S. C. Jiang, X. X. Zhang, X. X. Zhang, } "Mathematical modeling of dynamic laser coagulation during laser-induced interstitial thermotherapy", Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 604709 (27 October 2006); doi: 10.1117/12.709824; https://doi.org/10.1117/12.709824
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