27 October 2006 Design and evaluation of a portable continuous-wave NIR topography instrument
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Proceedings Volume 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine; 60470X (2006) https://doi.org/10.1117/12.710686
Event: Fourth International Conference on Photonics and Imaging in Biology and Medicine, 2005, Tianjin, China
Abstract
Near Infrared Spectroscopy (NIRS) has been widely used to access the brain functional activity non-invasively. A portable, multi-channel, continuous-wave (CW) NIR topography instrument we designed to measure the concentration changes of each hemoglobin species and map cerebral cortex functional activation. The probe of instrument consists of 4 LEDs operating at three-wavelength (735 nm & 805 nm & 850 nm) surrounded with 10 photodiodes mounted on a flexible PCB with the interoptode distance up to 2.88cm. On the basis of the modified Beer-Lambert law, the ratios of optical density changes in a ftilly oxygenated and deoxygenated state are determined by varying blood volume and hemoglobin oxygenation state in model experiment. The average ratios are 0.56. 1.74 and 0.45. Additionally, study on the phantoms is carried out to investigate the penetration depth (13 mm) of the sensor array.
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Yi Zheng, Yi Zheng, Zhili Zhang, Zhili Zhang, Qian Liu, Qian Liu, Chuanhua Cao, Chuanhua Cao, Hui Gong, Hui Gong, } "Design and evaluation of a portable continuous-wave NIR topography instrument", Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 60470X (27 October 2006); doi: 10.1117/12.710686; https://doi.org/10.1117/12.710686
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