Cell cycle dependence of protophorphyrin IX generation in 9L rat gliosarcoma

Shiming Luo; Xing Da; Qun Chen

doi:10.1117/12.710931

27 October 2006 Cell cycle dependence of protophorphyrin IX generation in 9L rat gliosarcoma

Shiming Luo, Xing Da, Qun Chen

Proceedings Volume 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine; 60473A (2006) https://doi.org/10.1117/12.710931
Event: Fourth International Conference on Photonics and Imaging in Biology and Medicine, 2005, Tianjin, China

Abstract

Photodynamic therapy (PDT) is a cancer therapy that utilizes optical energy to activate a photosensitizer drug in a target tissue. Always, the curative effect is dependent on the light fluence, the concentration of the photosensitizer and the concentration of the oxygen. To date, Protophorphyrin IX (PpIX) as the only one endogenous photosensitizer is widely used in PDT of brain tumors. Since PpIX is synthesized in intracellular structure, and is likely dependent on the phase of the cell cycle. The cell cycle dependence of PpIX production is thus investigated in the current work in 9L gliosarcoma cells.

Citation Download Citation

Shiming Luo, Xing Da, and Qun Chen "Cell cycle dependence of protophorphyrin IX generation in 9L rat gliosarcoma", Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 60473A (27 October 2006); https://doi.org/10.1117/12.710931

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