Fundamentals and developments of biological tissue optical clearing

Jingying Jiang; Kexin Xu

doi:10.1117/12.710978

27 October 2006 Fundamentals and developments of biological tissue optical clearing

Jingying Jiang, Kexin Xu

Proceedings Volume 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine; 604744 (2006) https://doi.org/10.1117/12.710978
Event: Fourth International Conference on Photonics and Imaging in Biology and Medicine, 2005, Tianjin, China

Abstract

This talk reviews the state ofthe art of tissue optical clearing techniques in biomedical optics. Following an analysis of the fundamentals of tissue optical clearing, the techniques of tissue optical clearing, especially by the use of biocompatible hyperosmotic agents onto biological tissue, are introduced. The review concludes that under the consideration of clinical safety issue and optical application, the optical clearing by using hyperosmotically active agents would be optimal method to enhance the light penetration depth and improve the imaging contrast, finally facilitate the application of light-based optical diagnostic and therapeutic techniques.

Citation Download Citation

Jingying Jiang and Kexin Xu "Fundamentals and developments of biological tissue optical clearing", Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 604744 (27 October 2006); https://doi.org/10.1117/12.710978

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