Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)

Susanne D. Giattina; Brian K. Courtney; Paul R. Herz; Michelle Harman; Sonya Shortkroff; Debra L. Stamper; Bin Liu; James G. Fujimoto; Mark E. Brezinski

doi:10.1117/12.646494

22 February 2006 Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)

Susanne D. Giattina, Brian K. Courtney, Paul R. Herz, Michelle Harman, Sonya Shortkroff, Debra L. Stamper, Bin Liu, James G. Fujimoto, Mark E. Brezinski

Author Affiliations +

Proceedings Volume 6078, Photonic Therapeutics and Diagnostics II; 60782C (2006) https://doi.org/10.1117/12.646494
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Current evidence indicates that most plaques classified as vulnerable or ruptured plaques do not lead to unstable angina or myocardial infarction. Improved methods are needed to risk stratify plaques to identify those which lead to most acute coronary syndromes. Collagen depletion in the intima overlying lipid collections appears to be a critical component of unstable plaques. In this study, we use polarization sensitive optical coherence tomography (PS-OCT) for the assessment of coronary plaque collagen. Collagen is birefringent, meaning that different polarization states travel through it at different velocities. Changes in PS-OCT images are a measure of tissue birefringence. Twenty-two coronary artery segments were imaged with PS-OCT and analyzed by picrosirius staining (a measure of collagen intensity and fiber size) and trichrome blue. The regression plot between PS-OCT changes and measured collagen yielded a correlation coefficient value of 0.475 (p<0.002). Good correlation was noted between two blinded investigators both with respect to PS-OCT measurements as well as luminosity as assessed by picrosirius. The predictive value of a PS-OCT measurement of negligible birefringence (less than 33% change) for minimal collagen was 93% while the predictive value of high birefringence (greater than 66% change) for high collagen concentrations was 89%. The effect of fiber type (chemical composition) was minimal relative to the effect due to fiber concentration. The capability of PS-OCT to assess plaque collagen content, in addition to its ability to generate high resolution structural assessments, make it a potentially powerful technology for identifying high risk plaques.

Citation Download Citation

Susanne D. Giattina, Brian K. Courtney, Paul R. Herz, Michelle Harman, Sonya Shortkroff, Debra L. Stamper, Bin Liu, James G. Fujimoto, and Mark E. Brezinski "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60782C (22 February 2006); https://doi.org/10.1117/12.646494

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available