22 February 2006 Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system
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Abstract
An in-vivo tumor model composed of multicellular human glioma spheroids implanted on a shell-less chorioallantoic membrane (CAM), has been developed. Following removal of a portion of the ectodermal epithelium layer of the CAM, human glioma spheroids were implanted on day 7 of embryonic development. Tumor invasion, rapid growth and vasculature formation were observed 7 days post implantation. Single tumor cell migration towards blood vessels, angiogenesis and satellite tumor growth were also evident. The human tumor/CAM model is being used to examine the effects of combined ALA PDT and anti-angiogenic agents. The shell-less CAM is well suited for topical, i.p. and i.v. photosensitizer and/or drug application.
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Nzola De Magalhães, Nzola De Magalhães, Lih-Huei L. Liaw, Lih-Huei L. Liaw, Linda Li, Linda Li, Angela Liogys, Angela Liogys, Steen J. Madsen, Steen J. Madsen, Henry Hirschberg, Henry Hirschberg, Bruce J. Tromberg, Bruce J. Tromberg, } "Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607830 (22 February 2006); doi: 10.1117/12.668795; https://doi.org/10.1117/12.668795
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