22 February 2006 Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system
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Abstract
An in-vivo tumor model composed of multicellular human glioma spheroids implanted on a shell-less chorioallantoic membrane (CAM), has been developed. Following removal of a portion of the ectodermal epithelium layer of the CAM, human glioma spheroids were implanted on day 7 of embryonic development. Tumor invasion, rapid growth and vasculature formation were observed 7 days post implantation. Single tumor cell migration towards blood vessels, angiogenesis and satellite tumor growth were also evident. The human tumor/CAM model is being used to examine the effects of combined ALA PDT and anti-angiogenic agents. The shell-less CAM is well suited for topical, i.p. and i.v. photosensitizer and/or drug application.
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Nzola De Magalhães, Nzola De Magalhães, Lih-Huei L. Liaw, Lih-Huei L. Liaw, Linda Li, Linda Li, Angela Liogys, Angela Liogys, Steen J. Madsen, Steen J. Madsen, Henry Hirschberg, Henry Hirschberg, Bruce J. Tromberg, Bruce J. Tromberg, "Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607830 (22 February 2006); doi: 10.1117/12.668795; https://doi.org/10.1117/12.668795
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