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22 February 2006 Functional and behavioral metrics for evaluating laser retinal damage
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The use of lasers by both the military and civilian community is rapidly expanding. Thus, the potential for and severity of laser eye injury and retinal damage is increasing. Sensitive and accurate methods to evaluate and follow laser retinal damage are needed. The multifocal electroretinogram (mfERG) has the potential to meet these criteria. In this study, the mfERG was used to evaluate changes to retinal function following laser exposure. Landolt C contrast acuity was also measured in the six behaviorally trained Rhesus monkeys. The monkeys then received Nd:YAG laser lesions (1064 nm, 9 ns pulse width) in each eye. One eye received a single foveal lesion of approximately 0.13 mJ total intraocular exposure (TIE) and the other received six parafoveal lesions which varied in TIE from 0.13 to 4 mJ. mfERGs and behavioral data were collected both pre- and post-exposure. mfERGs were recorded using stimuli that contained 103, 241, and 509 hexagons. Landolt C contrast acuity was measured with five sizes of Landolt C (0.33 to 11.15 cycles/degree) of varying contrast. mfERG response densities were sensitive to the functional retinal changes caused by the laser insult. In general, larger lesions showed greater mfERG abnormalities than smaller laser lesions. Deficits in contrast acuity were found to be more severe in the eyes with foveal injuries. Although the mfERG and contrast acuity assess different areas of the visual system, both are sensitive to laser-induced retinal damage and may be complementary tests for laser eye injury triage.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Cheryl D. DiCarlo, Gary L. Martinsen, Thomas Garza, Andres Grado, Juan Morin, Araceli Brown, David Stolarski, and Clarence Cain "Functional and behavioral metrics for evaluating laser retinal damage", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607837 (22 February 2006); doi: 10.1117/12.652232;

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