20 February 2006 Digital holographic optical coherence imaging of tumor tissue
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Abstract
Holographic Optical Coherence Imaging (OCI) uses spatial heterodyne detection in direct analogy with the temporal heterodyne detection of time-domain OCT. The spatial demodulator can be a sensitive dynamic holographic film or can be a CCD array placed directly at the hologram plane. We show that a digital hologram captured at the Fourier plane requires only a simple 2D inverse FFT of the digital hologram to compute the real image and its conjugate. Our recording on the optical Fourier plane has an advantage for diffuse targets because the intensity distribution of diffuse targets is relatively uniform at the Fourier plane and hence uses the full dynamic range of CCD camera. We applied this technique to human liver tumor spheroids and produced depth-resolved images to depth of 1.4 mm.
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Kwan Jeong, John J. Turek, David D. Nolte, "Digital holographic optical coherence imaging of tumor tissue", Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 60791G (20 February 2006); doi: 10.1117/12.646686; https://doi.org/10.1117/12.646686
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