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25 February 2006 Time-domain terahertz spectroscopy of artificial skin
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Abstract
Time-domain Terahertz (THz) spectroscopy and imaging is currently evaluated as a novel tool for medical imaging and diagnostics. The application of THz-pulse imaging of human skin tissues and related cancers has been demonstrated recently in-vitro and in-vivo. With this in mind, we present a time-domain THz-transmission study of artificial skin. The skin samples consist of a monolayer of porous matrix of fibers of cross-linked bovine tendon collagen and a glycosaminoglycan (chondroitin-6-sulfate) that is manufactured with a controlled porosity and defined degradation rate. Another set of samples consists of the collagen monolayer covered with a silicone layer. We have measured the THz-transmission and determined the index of refraction and absorption of our samples between 0.1 and 3 THz for various states of hydration in distilled water and saline solutions. The transmission of the THz-radiation through the artificial skin samples is modeled by electromagnetic wave theory. Moreover, the THz-optical properties of the artificial skin layers are compared to the THz-optical properties of freshly excised human skin samples. Based on this comparison the potential use of artificial skin samples as photo-medical phantoms for human skin is discussed.
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Peter M. Corridon, Ricardo Ascázubi, Courtney Krest, and Ingrid Wilke "Time-domain terahertz spectroscopy of artificial skin", Proc. SPIE 6080, Advanced Biomedical and Clinical Diagnostic Systems IV, 608007 (25 February 2006); https://doi.org/10.1117/12.646632
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