Instrumentation of rapid near-infrared diffuse optical tomography for imaging of tissue at 35 frames per second

Daqing Piao; Shudong Jiang; Hamid Dehghani; Subhadra Srinivasan; Brian W. Pogue

doi:10.1117/12.646619

13 February 2006 Instrumentation of rapid near-infrared diffuse optical tomography for imaging of tissue at 35 frames per second

Daqing Piao, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, Brian W. Pogue

Author Affiliations +

Proceedings Volume 6081, Multimodal Biomedical Imaging; 60810N (2006) https://doi.org/10.1117/12.646619
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

This paper presents the design, instrumentation, and performance of a rapid imaging near-infrared diffuse optical tomography system that is capable of collecting tomographic measurements at 35 frames per second. The video-rate tomographic data acquisition is achieved by spectral wavelength encoding of the sources, which allows many sources to be input into the tissue at the same time, followed by spectral-decoding of all detection channels in parallel using a spectrometer and CCD detector. The combination of spectral-decoding of the source lights horizontally in a spectrometer and spatial-separation of the detector positions vertically at the entrance slit provides continuous data for the entire set of source-detector pairs. A data acquisition speed of 35Hz frame rate was achieved with the use of the CCD operating in frame-transfer mode. The described system features 8 sources at an overall 785nm center band with average of 1.25nm spacing in wavelength and 8 detectors evenly deployed in a 27mm array designed for imaging with small animal tissues. The system's imaging characteristics as well as examples of capturing transient changes of absorption in the dynamic phantom are presented.

Citation Download Citation

Daqing Piao, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, and Brian W. Pogue "Instrumentation of rapid near-infrared diffuse optical tomography for imaging of tissue at 35 frames per second", Proc. SPIE 6081, Multimodal Biomedical Imaging, 60810N (13 February 2006); https://doi.org/10.1117/12.646619

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