Design of an in vivo multi-spectral confocal microendoscope for clinical trials

Andrew R. Rouse; Anthony A. Tanbakuchi; Joshua A. Udovich; Arthur F. Gmitro

doi:10.1117/12.646913

23 February 2006 Design of an in vivo multi-spectral confocal microendoscope for clinical trials

Andrew R. Rouse, Anthony A. Tanbakuchi, Joshua A. Udovich, Arthur F. Gmitro

Proceedings Volume 6082, Endoscopic Microscopy; 608205 (2006) https://doi.org/10.1117/12.646913
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We previously reported on the development and testing of a multi-spectral confocal microendoscope. Here we present a new system that will be used during an early stage clinical trial. The new microendoscope is significantly smaller, uses fewer optical elements, and is structurally more robust. The slit-scanning confocal system employs two synchronized single-axes scan mirrors and an externally coupled imaging catheter with automated focus control and dye delivery systems. In grayscale collection mode the confocal microendoscope operates at 30 frames-per-second with 3μm lateral resolution and 25μm axial resolution. The multi-spectral collection mode operates at 0.5 frames-per-second when acquiring 32 spectral channels with an average minimum resolvable wavelength difference of 12nm. The system will be used, in grayscale mode, to image ovaries during a small scale clinical trial on women undergoing oophorectomy. Recent grayscale and multi-spectral imaging results from ex-vivo human tissues are presented.

Citation Download Citation

Andrew R. Rouse, Anthony A. Tanbakuchi, Joshua A. Udovich, and Arthur F. Gmitro "Design of an in vivo multi-spectral confocal microendoscope for clinical trials", Proc. SPIE 6082, Endoscopic Microscopy, 608205 (23 February 2006); https://doi.org/10.1117/12.646913

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