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23 February 2006 Design of an in vivo multi-spectral confocal microendoscope for clinical trials
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Proceedings Volume 6082, Endoscopic Microscopy; 608205 (2006) https://doi.org/10.1117/12.646913
Event: SPIE BiOS, 2006, San Jose, California, United States
Abstract
We previously reported on the development and testing of a multi-spectral confocal microendoscope. Here we present a new system that will be used during an early stage clinical trial. The new microendoscope is significantly smaller, uses fewer optical elements, and is structurally more robust. The slit-scanning confocal system employs two synchronized single-axes scan mirrors and an externally coupled imaging catheter with automated focus control and dye delivery systems. In grayscale collection mode the confocal microendoscope operates at 30 frames-per-second with 3μm lateral resolution and 25μm axial resolution. The multi-spectral collection mode operates at 0.5 frames-per-second when acquiring 32 spectral channels with an average minimum resolvable wavelength difference of 12nm. The system will be used, in grayscale mode, to image ovaries during a small scale clinical trial on women undergoing oophorectomy. Recent grayscale and multi-spectral imaging results from ex-vivo human tissues are presented.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrew R. Rouse, Anthony A. Tanbakuchi, Joshua A. Udovich, and Arthur F. Gmitro "Design of an in vivo multi-spectral confocal microendoscope for clinical trials", Proc. SPIE 6082, Endoscopic Microscopy, 608205 (23 February 2006); https://doi.org/10.1117/12.646913
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