6 March 2006 In vivo functional photoacoustic tomography of traumatic brain injury in rats
Author Affiliations +
Abstract
In this study, we demonstrate the potential of photoacoustic tomography for the study of traumatic brain injury (TBI) in rats in vivo. Based on spectroscopic photoacoustic tomography that can detect the absorption rates of oxy- and deoxy-hemoglobins, the blood oxygen saturation and total blood volume in TBI rat brains were visualized. Reproducible cerebral trauma was induced using a fluid percussion TBI device. The time courses of the hemodynamic response following the trauma initiation were imaged with multi-wavelength photoacoustic tomography with bandwidth-limited spatial resolution through the intact skin and skull. In the pilot set of experiments, trauma induced hematomas and blood oxygen saturation level changes were detected, a finding consistent with the known physiological responses to TBI. This new imaging method will be useful for future studies on TBI-related metabolic activities and the effects of therapeutic agents.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jung-Taek Oh, Kwang-Hyun Song, Meng-Lin Li, George Stoica, Lihong V. Wang, "In vivo functional photoacoustic tomography of traumatic brain injury in rats", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860P (6 March 2006); doi: 10.1117/12.645378; http://dx.doi.org/10.1117/12.645378
PROCEEDINGS
7 PAGES


SHARE
KEYWORDS
Traumatic brain injury

Brain

Blood

Neuroimaging

Photoacoustic tomography

Injuries

In vivo imaging

Back to Top