6 March 2006 In vivo functional photoacoustic tomography of traumatic brain injury in rats
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In this study, we demonstrate the potential of photoacoustic tomography for the study of traumatic brain injury (TBI) in rats in vivo. Based on spectroscopic photoacoustic tomography that can detect the absorption rates of oxy- and deoxy-hemoglobins, the blood oxygen saturation and total blood volume in TBI rat brains were visualized. Reproducible cerebral trauma was induced using a fluid percussion TBI device. The time courses of the hemodynamic response following the trauma initiation were imaged with multi-wavelength photoacoustic tomography with bandwidth-limited spatial resolution through the intact skin and skull. In the pilot set of experiments, trauma induced hematomas and blood oxygen saturation level changes were detected, a finding consistent with the known physiological responses to TBI. This new imaging method will be useful for future studies on TBI-related metabolic activities and the effects of therapeutic agents.
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Jung-Taek Oh, Jung-Taek Oh, Kwang-Hyun Song, Kwang-Hyun Song, Meng-Lin Li, Meng-Lin Li, George Stoica, George Stoica, Lihong V. Wang, Lihong V. Wang, } "In vivo functional photoacoustic tomography of traumatic brain injury in rats", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860P (6 March 2006); doi: 10.1117/12.645378; https://doi.org/10.1117/12.645378

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