Toward very high resolution imaging in ultrasound-modulated optical tomography of biological tissues

Sava Sakadžić; Sri-Rajasekhar Kothapalli; Lihong V. Wang

doi:10.1117/12.645285

6 March 2006 Toward very high resolution imaging in ultrasound-modulated optical tomography of biological tissues

Sava Sakadžić, Sri-Rajasekhar Kothapalli, Lihong V. Wang

Proceedings Volume 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 608614 (2006) https://doi.org/10.1117/12.645285
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We explored the possibility of applying very high ultrasound frequencies to achieve very high resolution in ultrasound-modulated optical tomography of soft biological tissues. The ultrasound-modulated coherent light that traversed the scattering biological tissue was detected by a long-cavity and a large etendue confocal Fabry- Perot interferometer. We used various focused ultrasound transducers of 15 MHz, 30 MHz, and 50 MHz to obtain two dimensional images of optically absorbing objects positioned at a few millimeters depth below the surface of both optically scattering phantoms and soft biological tissue samples. This technology is complementary to other imaging technologies, such as confocal microscopy and optical-coherence tomography, and has potential for broad biomedical applications.

Citation Download Citation

Sava Sakadžić, Sri-Rajasekhar Kothapalli, and Lihong V. Wang "Toward very high resolution imaging in ultrasound-modulated optical tomography of biological tissues", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 608614 (6 March 2006); https://doi.org/10.1117/12.645285

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