6 March 2006 Virtual-detector synthetic aperture focusing technique with application in in vivo photoacoustic microscopy
Author Affiliations +
Abstract
In this study, we introduce a synthetic aperture focusing technique which employs a virtual detector concept, combined with coherence weighting, to extend the depth of focus for an in-vivo photoacoustic microscopy system. This technique treats the transducer's focal point as a virtual point detector of photoacoustic signals, delays adjacent scan lines relative to the virtual detector, and then sums the delayed signals to achieve focusing in the out-of-focus region. In addition, a coherence factor among the delayed signals for each synthesized imaging point is used as a weighting factor to further improve the focusing quality. Images of an Intralipid phantom containing a carbon fiber show how this technique improves the -6 dB lateral resolution from 49-379 μm to 46-53 μm and increases the SNR by 0-29 dB, depending on the distance from the ultrasonic focal point. In vivo experiments show that this technique also provides a clearer tumorassociated angiogenesis in the mouse's scalp. The extended depth of focus for the photoacoustic microscopy system enables 3D reconstruction of the vascular network for the study of tumor angiogenesis.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Meng-Lin Li, Meng-Lin Li, Hao F. Zhang, Hao F. Zhang, Konstantin Maslov, Konstantin Maslov, George Stoica, George Stoica, Lihong V. Wang, Lihong V. Wang, } "Virtual-detector synthetic aperture focusing technique with application in in vivo photoacoustic microscopy", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60861F (6 March 2006); doi: 10.1117/12.645115; https://doi.org/10.1117/12.645115
PROCEEDINGS
8 PAGES


SHARE
RELATED CONTENT


Back to Top