In vivo multiphoton tomography of skin cancer

Karsten König; Iris Riemann; Alexander Ehlers; Rainer Buckle; Enrico Dimitrow; Martin Kaatz; Joachim Fluhr; Peter Elsner

doi:10.1117/12.646000

23 February 2006 In vivo multiphoton tomography of skin cancer

Karsten König; Iris Riemann; Alexander Ehlers; Rainer Buckle; Enrico Dimitrow; Martin Kaatz; Joachim Fluhr; Peter Elsner

Author Affiliations +

Proceedings Volume 6089, Multiphoton Microscopy in the Biomedical Sciences VI; 60890R (2006) https://doi.org/10.1117/12.646000
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The multiphoton tomograph DermaInspect was used to perform first clinical studies on the early non-invasive detection of skin cancer based on non-invasive optical sectioning of skin by two-photon autofluorescence and second harmonic generation. In particular, deep-tissue pigmented lesions -nevi- have been imaged with intracellular resolution using near infrared (NIR) femtosecond laser radiation. So far, more than 250 patients have been investigated. Cancerous tissues showed significant morphological differences compared to normal skin layers. In the case of malignant melanoma, the occurrence of luminescent melanocytes has been detected. Multiphoton tomography will become a novel non-invasive method to obtain high-resolution 3D optical biopsies for early cancer detection, treatment control, and in situ drug screening.

Citation Download Citation

Karsten König, Karsten König, Iris Riemann, Iris Riemann, Alexander Ehlers, Alexander Ehlers, Rainer Buckle, Rainer Buckle, Enrico Dimitrow, Enrico Dimitrow, Martin Kaatz, Martin Kaatz, Joachim Fluhr, Joachim Fluhr, Peter Elsner, Peter Elsner, } "In vivo multiphoton tomography of skin cancer", Proc. SPIE 6089, Multiphoton Microscopy in the Biomedical Sciences VI, 60890R (23 February 2006); doi: 10.1117/12.646000; https://doi.org/10.1117/12.646000

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years