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23 February 2006 Detection of collagen by second harmonic microscopy as a diagnostic tool for liver fibrosis
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Abstract
Liver fibrosis has many causes, including hepatitis C, alcohol abuse, and non-alcoholic steatohepatitis. It is characterized by abnormal deposition of extracellular matrix proteins, mainly collagen. The deposition of these proteins results in impaired liver function caused by distortion of the hepatic architecture by fibrous scar tissue. The unique triple helix structure of collagen and high level of crystallinity make it very efficient for generating second harmonic signals. In this study we have set out to see if second harmonic imaging of collagen can be used as a non-biased quantitative tool for classification of fibrosis levels in liver biopsies and if it can detect early fibrosis formation not detected by current methods.
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Maruth Banavar, Eleanor P. W. Kable, Filip Braet, X. M. Wang, M. D. Gorrell, and Guy Cox "Detection of collagen by second harmonic microscopy as a diagnostic tool for liver fibrosis", Proc. SPIE 6089, Multiphoton Microscopy in the Biomedical Sciences VI, 60891B (23 February 2006); https://doi.org/10.1117/12.649452
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