10 February 2006 Blood compatibility of artificial blood vessels probed by infrared spectroscopic imaging
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Proceedings Volume 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry; 609302 (2006); doi: 10.1117/12.644997
Event: SPIE BiOS, 2006, San Jose, California, United States
Abstract
The determination of protein structure and function plays an important role in biomedical and biochemical research. Common techniques that give full structural information do not permit in-vivo measurements. Infrared spectroscopy has a sufficient sensitivity to examine the structure of proteins solution under in-situ conditions and even on surfaces. However, measurements at few spots on the surface are not suitable to find out the blood compatibility of the protein layer, because the changes in conformation occur often in small domains. Here we report on the investigations of adsorbed fibrinogen with FTIR imaging. FTIR imaging permits an identification of coagulation spots in the micrometer range and the identification of coagulation spots on the implant material.
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Gerald Steiner, Manfred Maitz, Sibel Tunc, Reiner Salzer, "Blood compatibility of artificial blood vessels probed by infrared spectroscopic imaging", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 609302 (10 February 2006); doi: 10.1117/12.644997; https://doi.org/10.1117/12.644997
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KEYWORDS
Proteins

Blood

FT-IR spectroscopy

Spectroscopy

Adsorption

Imaging spectroscopy

Infrared spectroscopy

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