Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma

J. Chaiken; Katie Ellis; Patrick Eslick; Lauren Piacente; Ethan Voss

doi:10.1117/12.659219

27 February 2006 Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma

J. Chaiken, Katie Ellis, Patrick Eslick, Lauren Piacente, Ethan Voss

Proceedings Volume 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry; 609305 (2006) https://doi.org/10.1117/12.659219
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We have refined of our previously published tissue modulation technique for obtaining Raman spectra of blood in fingertip capillary beds. Results from the newest LighTouch device benefit from more consistent management of applied force and temperature and more consistent tissue placement. Comparing these more precisely obtained spectra with other spectra obtained from the same capillary beds using the natural heart driven pulse as modulation reveals essential aspects of microcirculation such as plasma skimming, the Faraeus effect and the Faraeus-Lindqvist effect. We discuss these results in the context of performing noninvasive quantitative analysis of blood and blood components in vivo. We show the first Raman spectra of human blood plasma noninvasive, in vivo.

Citation Download Citation

J. Chaiken, Katie Ellis, Patrick Eslick, Lauren Piacente, and Ethan Voss "Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 609305 (27 February 2006); https://doi.org/10.1117/12.659219

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