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27 February 2006 Feasibility of detecting peptide phosphorylation by surface enhanced Raman scattering
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Abstract
We report on the feasibility of surface enhanced Raman scattering (SERS) as a highly sensitive technique for detecting peptide phosphorylation. Compared with existing techniques for quantifying peptide phosphorylation, such as high-performance liquid chromatography (HPLC), the short scanning and processing time associated with SERS makes it an attractive alternative for measurement on a near-real-time basis at sub micro-molar concentrations. Using the recently reported drop-coating deposition Raman method we compare our SERS spectra to normal Raman spectra that would otherwise be unobtainable at such low concentration.
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J. Moger and C.P. Winlove "Feasibility of detecting peptide phosphorylation by surface enhanced Raman scattering", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930G (27 February 2006); https://doi.org/10.1117/12.644168
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