27 February 2006 Application of NIR Raman spectroscopy for detecting and characterizing early dental caries
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Abstract
Early dental caries detection facilitates implementation of non-surgical methods for arresting caries progression and promoting tooth remineralization. We present a method based on Raman spectroscopy with near-IR laser excitation to provide biochemical contrast for detecting and characterizing incipient carious lesions found in extracted human teeth. Changes in Raman spectra are observed in PO43- vibrations arising from hydroxyapatite of mineralized tooth tissue. Examination of various intensities of the PO43- ν2, ν3, ν4 vibrations showed consistent increased intensities in spectra of carious lesions compared to sound enamel. The spectral changes are attributed to demineralization-induced alterations of enamel crystallite morphology and/or orientation. This hypothesis is supported by reduced Raman polarization anisotropy derived from polarized Raman spectra of carious lesions. Polarized Raman spectral imaging of carious lesions found on whole (i.e. un-sectioned) tooth samples will also be presented.
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A. C.-T. Ko, A. C.-T. Ko, L.-P. Choo-Smith, L.-P. Choo-Smith, R. Zhu, R. Zhu, M. Hewko, M. Hewko, C. Dong, C. Dong, B. Cleghorn, B. Cleghorn, M. G. Sowa, M. G. Sowa, } "Application of NIR Raman spectroscopy for detecting and characterizing early dental caries", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930L (27 February 2006); doi: 10.1117/12.647159; https://doi.org/10.1117/12.647159
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