Tip-enhanced Raman scattering of a DNA binding compound

Akiko Rasmussen; Christian Budich; Volker Deckert

doi:10.1117/12.646274

27 February 2006 Tip-enhanced Raman scattering of a DNA binding compound

Akiko Rasmussen, Christian Budich, Volker Deckert

Proceedings Volume 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry; 60930Z (2006) https://doi.org/10.1117/12.646274
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Tip-enhanced Raman scattering (TERS), a scattering type scanning near-field optical microscope (s-SNOM), is a technique which combines Raman spectroscopy with an optically active silver coated scanning probe microscopy tip. Only the molecules located in a small area close to the tip apex will experience the field enhancement. This provides a unique tool to obtain highly enhanced Raman signals together with a high lateral-resolution. In this paper, preliminary investigation of the interaction between methylene blue and calf-thymus double-stranded (ds) DNA has been carried out by SERS. Furthermore, TERS spectra of methylene blue have been collected for the first time, and are compared with standard surface enhanced Raman scattering (SERS). The results are discussed in terms of possible biological applications.

Citation Download Citation

Akiko Rasmussen, Christian Budich, and Volker Deckert "Tip-enhanced Raman scattering of a DNA binding compound", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930Z (27 February 2006); https://doi.org/10.1117/12.646274

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available