27 February 2006 Tip-enhanced Raman scattering of a DNA binding compound
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Abstract
Tip-enhanced Raman scattering (TERS), a scattering type scanning near-field optical microscope (s-SNOM), is a technique which combines Raman spectroscopy with an optically active silver coated scanning probe microscopy tip. Only the molecules located in a small area close to the tip apex will experience the field enhancement. This provides a unique tool to obtain highly enhanced Raman signals together with a high lateral-resolution. In this paper, preliminary investigation of the interaction between methylene blue and calf-thymus double-stranded (ds) DNA has been carried out by SERS. Furthermore, TERS spectra of methylene blue have been collected for the first time, and are compared with standard surface enhanced Raman scattering (SERS). The results are discussed in terms of possible biological applications.
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Akiko Rasmussen, Christian Budich, Volker Deckert, "Tip-enhanced Raman scattering of a DNA binding compound", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930Z (27 February 2006); doi: 10.1117/12.646274; https://doi.org/10.1117/12.646274
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