27 February 2006 The feasibility investigation of non-invasive blood glucose sensing based on near-infrared spectroscopy
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Proceedings Volume 6094, Optical Diagnostics and Sensing VI; 60940J (2006); doi: 10.1117/12.645386
Event: SPIE BiOS, 2006, San Jose, California, United States
Abstract
We have performed transcutaneous measurement and vessel bypass measurement to obtain the skin spectra and the blood vessel spectra respectively over the 1100-1700nm in the animal trial. The aim of this study is to validate the feasibility of the near-infrared (NIR) spectroscopy as a non-invasive blood glucose monitoring method, in particular during clinically relevant fluctuation in blood glucose. Two steps are adopted to evaluate the correlation between the skin diffusion spectra and the blood vessel transmission spectra. First, the variation tendencies of the skin and the blood vessel spectra were evaluated, and the partial least square (PLS) regression was adopted to establish the calibration model between the skin spectra, the vessel spectra and the corresponding concentration respectively. Then, the correlation analysis method is used to describe the relationship between the two kinds of spectra mentioned above. The correlation between the skin and the vessel spectra will be a powerful proof to demonstrate the correlation between the skin spectra and the blood glucose concentration.
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Xiaoyu Gu, Bin Deng, Lin An, Wenliang Chen, Kexin Xu, "The feasibility investigation of non-invasive blood glucose sensing based on near-infrared spectroscopy", Proc. SPIE 6094, Optical Diagnostics and Sensing VI, 60940J (27 February 2006); doi: 10.1117/12.645386; http://dx.doi.org/10.1117/12.645386
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KEYWORDS
Glucose

Blood

Skin

Near infrared spectroscopy

Calibration

Veins

Arteries

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