28 February 2006 Magnetic resonance temperature imaging of nanoshell photo-thermal therapy
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A novel thermal therapy delivery technique using low power near infrared irradiation delivered to a distribution of gold-silica nanoshell particles under MR-guidance has been recently introduced. This research expands upon the previous research by using MR temperature imaging as a tool to investigate the spatiotemporal temperature distribution associated with accumulations of nanoshells after an intravenous injection of nanoshells into tumor bearing mice. Tumors were inoculated and grown subcutaneously in mice and intravenously injected nanoshells were allowed to accumulate passively through the associated leaky vasculature. MRI was used in the planning and post-therapy evaluation of treated sites while realtime MR temperature imaging (MRTI) monitored the distribution of temperature within tissue during the procedure. MRTI was demonstrated to be an excellent tool for determining the extent of thermal energy delivered to the treatment region and could be useful for evaluating the efficiency of nanoshell uptake into a target tissue. This preliminary data demonstrates the feasibility of using MR-guidance for the control of in vivo nanoshell-based photo-thermal therapy. Furthermore, this feasibility study validates previous research that nanoshells will passively accumulate in tumor target tissues at clinically relevant concentrations.
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D. Patrick O'Neal, D. Patrick O'Neal, R. Jason Stafford, R. Jason Stafford, John D. Hazle, John D. Hazle, "Magnetic resonance temperature imaging of nanoshell photo-thermal therapy", Proc. SPIE 6095, Nanobiophotonics and Biomedical Applications III, 609505 (28 February 2006); doi: 10.1117/12.647184; https://doi.org/10.1117/12.647184

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