4 April 2006 Fluorescent core-shell silica nanoparticles: an alternative radiative materials platform
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We report on monodisperse fluorescent core-shell silica nanoparticles (C dots) with enhanced brightness and photostability as compared to parent free dye in aqueous solution. Dots containing either tetramethylrhodamine or 7-nitrobenz-2-oxa-1,3-diazole dyes with diameters ranging from tens of nanometers to microns are discussed. The benefits of the core-shell architecture are described in terms of enhanced fluorescent yield of the fluorophores in the quasi-solid-state environment within the particle as compared with parent free dye in water. Several applications of these particles in the fields of photonics and the life sciences are discussed. Specifically, fluorescent core-shell silica nanoparticles are investigated as an active medium for photonic building blocks assembled on zinc sulfide-based seed particles. Initial assembly results for these composite raspberry structures are shown. Finally, applications in the life sciences are explored, including targeting of specific antibody receptors using these single-emission nanoparticles. We expand on single-emission core-shell architecture to incorporate environmentally-sensitive fluorophores to create quantitative ratiometric nanoscale sensors capable of interrogating chemical concentrations on the sub-cellular to molecular levels and demonstrate initial results of intracellular pH imaging. The concept of a single particle laboratory (SPL) is introduced as an active investigator of its environment.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Erik Herz, Erik Herz, Andrew Burns, Andrew Burns, Stephanie Lee, Stephanie Lee, Prabuddha Sengupta, Prabuddha Sengupta, Daniel Bonner, Daniel Bonner, Hooisweng Ow, Hooisweng Ow, Chekesha Liddell, Chekesha Liddell, Barbara Baird, Barbara Baird, Ulrich Wiesner, Ulrich Wiesner, } "Fluorescent core-shell silica nanoparticles: an alternative radiative materials platform", Proc. SPIE 6096, Colloidal Quantum Dots for Biomedical Applications, 609605 (4 April 2006); doi: 10.1117/12.661782; https://doi.org/10.1117/12.661782

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